Basic Tumor Immunology

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8⁺ T cells without host preconditioning
Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Marshall A. Diven, Caroline W. Fugle, Andrew D. M. Kaiser, Claudia Wrzesinski, Bei Liu, Nicholas P. Restifo, Chrystal M. Paulos

Journal for ImmunoTherapy of Cancer Dec 2016, 4 (1) 6; DOI: 10.1186/s40425-016-0110-8
Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1⁺ regulatory B cell expansion
Linsen Ye, Qi Zhang, Yusheng Cheng, Xiaolong Chen, Guoying Wang, Mengchen Shi, Tong Zhang, Yingjiao Cao, Hang Pan, Liting Zhang, Genshu Wang, Yinan Deng, Yang Yang, Guihua Chen

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 145; DOI: 10.1186/s40425-018-0451-6
Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1
Zhi-Fa Wen, Hongxiang Liu, Rong Gao, Meng Zhou, Jie Ma, Yue Zhang, Jinjin Zhao, Yongqiang Chen, Tianyu Zhang, Fang Huang, Ning Pan, Jinping Zhang, Bernard A. Fox, Hong-Ming Hu, Li-Xin Wang

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 151; DOI: 10.1186/s40425-018-0452-5
PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8⁺ T-cell activity
Larissa S. Carnevalli, Charles Sinclair, Molly A. Taylor, Pablo Morentin Gutierrez, Sophie Langdon, Anna M. L. Coenen-Stass, Lorraine Mooney, Adina Hughes, Laura Jarvis, Anna Staniszewska, Claire Crafter, Ben Sidders, Elizabeth Hardaker, Kevin Hudson, Simon T. Barry

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 158; DOI: 10.1186/s40425-018-0457-0
Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
Grace Mahlbacher, Louis T. Curtis, John Lowengrub, Hermann B. Frieboes

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 10; DOI: 10.1186/s40425-017-0313-7
Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model
Yuri Kosinsky, Simon J. Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Helen Tomkinson, Nidal Al-Huniti, Donald R. Stanski, Gabriel Helmlinger

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 17; DOI: 10.1186/s40425-018-0327-9
An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides
Laura L. Eggink, Katherine F. Roby, Robert Cote, J. Kenneth Hoober

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 28; DOI: 10.1186/s40425-018-0339-5
RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer
Fanny Ledys, Quentin Klopfenstein, Caroline Truntzer, Laurent Arnould, Julie Vincent, Leila Bengrine, Romain Remark, Romain Boidot, Sylvain Ladoire, Francois Ghiringhelli, Valentin Derangere

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 123; DOI: 10.1186/s40425-018-0438-3
Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication
Gijs G. Zom, Marian M. J. H. P. Willems, Selina Khan, Tetje C. van der Sluis, Jan Willem Kleinovink, Marcel G. M. Camps, Gijsbert A. van der Marel, Dmitri V. Filippov, Cornelis J. M. Melief, Ferry Ossendorp

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 146; DOI: 10.1186/s40425-018-0455-2
1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis
Yutao Yan, Lei Chang, Hongzhe Tian, Lu Wang, Yawei Zhang, Tao Yang, Guohao Li, Weifeng Hu, Kavita Shah, Gang Chen, Yonglian Guo

Journal for ImmunoTherapy of Cancer Dec 2018, 6 (1) 148; DOI: 10.1186/s40425-018-0466-z

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