Most read article(s)
- Skull Base CSF Leaks: Potential Underlying Pathophysiology and Evaluation of Brain MR Imaging Findings Associated with Spontaneous Intracranial Hypotension
The purpose of this study was to use a validated brain MRI scoring system (Bern score) to evaluate patients with confirmed skull base CSF leaks for findings associated with SIH. The authors found that patients with skull base CSF leaks did not have brain MRI findings that are associated with SIH and likely have distinct pathophysiology from spinal CSF leaks.
- Low-Field Portable MR Imaging to Evaluate Ventricular Volumes: A Single-Center Retrospective Study
The authors compared low-field portable and standard MR images of ventricular volume in the same pediatric patient. They showed high correlation in the estimates of ventricular volume between the 2 types of MR imaging, without systemic bias.
- Alzheimer Disease Anti-Amyloid Immunotherapies: Imaging Recommendations and Practice Considerations for Monitoring of Amyloid-Related Imaging Abnormalities
This review discusses the 3 key MRI sequences for ARIA monitoring and standardized imaging protocols and provides imaging recommendations for 3 key patient scenarios. All patients on anti-amyloid immunotherapy should have T2* gradient-recalled echo (to evaluate for ARIA-H), 2D or 3D T2 FLAIR (to evaluate for ARIA-E), and DWI (to differentiate ARIA-E from acute ischemia). Patient imaging scenarios are 1) baseline dementia diagnosis/treatment enrollment evaluation, 2) asymptomatic ARIA monitoring, and 3) evaluation of the symptomatic patient on anti-amyloid immunotherapy.
- Gadolinium-Enhanced T2 FLAIR Is an Imaging Biomarker of Radiation Necrosis and Tumor Progression in Patients with Brain Metastases
Distinguishing radiation necrosis from tumor progression after radiation therapy for brain metastases is challenging on conventional MRI. This study demonstrated higher normalized contrast-enhanced T1 and T2 FLAIR signal intensity for RN. Contrast-enhanced T2 FLAIR signal intensity distinguished RN and TP with an AUC similar to that of DSC perfusion.
- Perspectives from the Inaugural “Spinal CSF Leak: Bridging the Gap” Conference: A Convergence of Clinical and Patient Expertise
The “Spinal CSF Leak: Bridging the Gap” Conference highlighted collective insights from a diverse cohort of clinicians, researchers, and patients. This manuscript discusses the clinical, diagnostic, and treatment challenges of spinal CSF leak, concluding that a collaborative, multidisciplinary care team needs to provide a standardized-yet-flexible diagnostic protocol to address the variability in clinical presentations and often-subtle radiographic findings.