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This study compared clinical outcomes in in-hospital strokes versus community-onset strokes in patients treated with endovascular thrombectomy for large-vessel occlusion. In-hospital strokes had overall faster time metrics from stroke onset to reperfusion. However, the rate of successful reperfusion and safety outcomes (in-hospital mortality and parenchymal hematoma) did not differ between the groups. Ninety-day mRS was also similar in both groups.

This systematic review and meta-analysis evaluated the risk of intracerebral hemorrhage, and its subtypes associated with mechanical thrombectomy with or without IV thrombolysis for the treatment of acute ischemic stroke due to large-vessel occlusion. The analysis showed that the overall risk of symptomatic intracerebral hemorrhage was comparable between mechanical thrombectomy with IV thrombolysis and mechanical thrombectomy alone.