- Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors
ASL was used to evaluate 54 children with recently diagnosed brain tumors using a pseudocontinuous technique and blood flow was calculated for all masses. Blood flow was higher in grade 3 and 4 tumors than in lower grade ones. Although ASL was unable to separate tumors by histology, perfusion was found to be higher in medulloblastomas than in pylocytic astrocytomas.
- No Evidence for Impairment of Venous Hemodynamics in Children or Young Adults with Pediatric-Onset Multiple Sclerosis
The results of venous sonography, contrast-enhanced MRI, and MR venography in 26 pediatric patients with MS were compared with controls and 13 young adults with pediatric-onset MS. The authors concluded that chronic cerebrospinal venous insufficiency is rarely observed in children or young adults with pediatric-onset MS as venous anatomy and flow rates showed normal outflow in most subjects.
- Diffusion MRI Improves the Accuracy of Preoperative Diagnosis of Common Pediatric Cerebellar Tumors among Reviewers with Different Experience Levels
DWI studies of 96 cerebellar pediatric tumors were analyzed by neuroradiologists and residents in radiology during 2 sessions, one that included the DWI studies and one that did not. These observers were asked to categorize the masses as: astrocytoma, medulloblastoma, ependymoma, or atypical teratoid/rhabdoid tumor. The addition of DWI resulted in significant improvement in the diagnosis of all tumors except ependymoma among all reviewers with different levels of experience.
- Incidental Findings in Youths Volunteering for Brain MRI Research
Incidental abnormalities seen in research MRI brain studies of 1400 “normal” volunteer individuals aged 8-23 years were assessed. Ten percent showed incidental findings and 12 of these required further follow-up. Findings were not related to age but whites had higher numbers of pineal cysts and males had a higher incidence of cavum septum pellucidum, which was associated with psychosis-related symptoms.
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