- Deep Medullary Vein Integrity and Relationships with Small Vessel Disease and Interstitial Diffusivity Measures in Patients with a Recent Small Subcortical Infarct
In this retrospective observational study, the authors assessed how DMV integrity relates to MRI-based SVD severity markers and glymphatic function assessed by DTI measures in patients with a recent small subcortical infarct. DMV disruption demonstrated a weak association with SVD, influenced by confounding factors, and a strong relationship with microstructural WM integrity and free water content, suggesting the potential involvement of extracellular fluid in mechanisms leading to vein disruption.
- Stroke Thrombectomy for Large Infarcts with Limited Penumbra: Systematic Review and Meta-Analysis of Randomized Trials
This meta-analysis evaluated randomized clinical trial results to provide more definitive guidance on the role of EVT for patients with stroke with large infarcts based on perfusion metrics. The results showed that the effectiveness of thrombectomy is uncertain regarding the safety and efficacy of thrombectomy for patients with limited areas of at-risk tissue. EVT may be beneficial for those with intermediate perfusion mismatch (ratio of 1.2-1.8 or volume of 10-15 mL) but not for those with low perfusion mismatch (ratio <1.2 or volume <10 mL).
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