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The authors reviewed clinical charts and images of patients 18 years of age or younger with ≥4 gadobenatedimeglumine–enhanced MRIs for 6 years. Seventy-six children (60 unconfounded by treatment, 16 with radiochemotherapy) met the selection criteria. T1 signal intensity ratios for the dentate to pons and globus pallidus to thalamus were calculated and correlated with number of injections, time interval, and therapy. Among the 60 children without radiochemotherapy, only 2 had elevated T1 signal intensity ratios. Twelve of the 16 children with radiochemotherapy showed elevated signal intensity ratios. Statistical analysis demonstrated a significant signal intensity ratio change for the number of injections. Compared with published adult series, children show a similar pattern of T1 hyperintense signal changes of the dentate and globus pallidus after multiple gadobenatedimeglumine injections. The T1 signal changes in children are accelerated by radiochemotherapy.