Immunotherapy

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting
Kristin M Snyder, Kate J Dixon, Zachary Davis, Martin Hosking, Geoffrey Hart, Melissa Khaw, Anders Matson, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007280; DOI: 10.1136/jitc-2023-007280
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007678; DOI: 10.1136/jitc-2023-007678
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
Jiaji Mao, Jianing Li, Junwei Chen, Qin Wen, Minghui Cao, Fang Zhang, Baoxun Li, Qinyuan Zhang, Zhe Wang, Jingzhong Zhang, Jun Shen

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007481; DOI: 10.1136/jitc-2023-007481
First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial
Alex De Caluwe, Emanuela Romano, Philip Poortmans, Andrea Gombos, Elisa Agostinetto, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Ligia Craciun, Isabelle Veys, Denis Larsimont, Marianne Paesmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Martine Piccart-Gebhart, Michail Ignatiadis, Laurence Buisseret

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007279; DOI: 10.1136/jitc-2023-007279
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion
Alexandra Rose Teagle, Patricia Castro-Sanchez, Rebecca J Brownlie, Nicola Logan, Simran S Kapoor, David Wright, Robert J Salmond, Rose Zamoyska

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007614; DOI: 10.1136/jitc-2023-007614
Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer
Elisa C Toffoli, Amanda A van Vliet, Henk W M Verheul, Hans J van der Vliet, Jurriaan Tuynman, Jan Spanholtz, Tanja D de Gruijl

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007554; DOI: 10.1136/jitc-2023-007554
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e008081; DOI: 10.1136/jitc-2023-008081
RIG-I promotes immune evasion of colon cancer by modulating PD-L1 ubiquitination
Yangyang Zhang, Lingxiu Zeng, Meng Wang, Zhenwei Yang, Hailin Zhang, Liping Gao, Ranran Zhang, Jialong Liu, Wenqing Shan, Ying Chang, Lan Liu, Qiu Zhao, Yong Li, Jing Liu

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007313; DOI: 10.1136/jitc-2023-007313
Identification of neoepitope reactive T-cell receptors guided by HLA-A*03:01 and HLA-A*11:01 immunopeptidomics
Catherine M Ade, Matthew J Sporn, Sudipto Das, Zhiya Yu, Ken-ichi Hanada, Yue A Qi, Tapan Maity, Xu Zhang, Udayan Guha, Thorkell Andresson, James C Yang

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007097; DOI: 10.1136/jitc-2023-007097
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos, Benjamin Izar

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006782; DOI: 10.1136/jitc-2023-006782

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