Immunotherapy

Complete metabolic response in patients with advanced non-small cell lung cancer with prolonged response to immune checkpoint inhibitor therapy
Justin Ferdinandus, Martin Metzenmacher, Lukas Kessler, Lale Umutlu, Clemens Aigner, Karl-Otto Kambartel, Viktor Grünwald, Wilfried Ernst Erich Eberhardt, Wolfgang Peter Fendler, Ken Herrmann, Martin Faehling, Daniel Christian Christoph

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002262; DOI: 10.1136/jitc-2020-002262
Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer
Anna Wilkins, Elisa Fontana, Gift Nyamundanda, Chanthirika Ragulan, Yatish Patil, David Mansfield, Jennifer Kingston, Fiona Errington-Mais, Daniel Bottomley, Katharina von Loga, Hannah Bye, Paul Carter, Emma Tinkler-Hundal, Arish Noshirwani, Jessica Downs, Magnus Dillon, Sandra Demaria, David Sebag-Montefiore, Kevin Harrington, Nick West, Alan Melcher, Anguraj Sadanandam

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001717; DOI: 10.1136/jitc-2020-001717
Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma
Yuxiang Ma, Xi Chen, Ao Wang, Hongyun Zhao, Qingguang Lin, Hua Bao, Yang Zhang, Shaodong Hong, Wanxiangfu Tang, Yan Huang, Yunpeng Yang, Xue Wu, Yang Shao, Wenfeng Fang, Li Zhang

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002014; DOI: 10.1136/jitc-2020-002014
Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer
Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K Kleczko, Raphael A Nemenoff, Sana D Karam

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002585; DOI: 10.1136/jitc-2021-002585
Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy
Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001764; DOI: 10.1136/jitc-2020-001764
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
François Anna, Elodie Bole-Richard, Joel LeMaoult, Marie Escande, Martin Lecomte, Jean-Marie Certoux, Philippe Souque, Francine Garnache, Olivier Adotevi, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001998; DOI: 10.1136/jitc-2020-001998
Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma
Alexander Chehrazi-Raffle, Luis Meza, Marice Alcantara, Nazli Dizman, Paulo Bergerot, Nicholas Salgia, JoAnn Hsu, Nora Ruel, Sabrina Salgia, Jasnoor Malhotra, Ewa Karczewska, Marcin Kortylewski, Sumanta Pal

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002009; DOI: 10.1136/jitc-2020-002009
Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer
Davide Melisi, Do-Youn Oh, Antoine Hollebecque, Emiliano Calvo, Anna Varghese, Erkut Borazanci, Teresa Macarulla, Valeria Merz, Camilla Zecchetto, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Leena Gandhi, Shawn T Estrem, Karim A Benhadji, Mark C Lanasa, Emin Avsar, Susan C Guba, Rocio Garcia-Carbonero

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002068; DOI: 10.1136/jitc-2020-002068
CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy
Xuan Guo, Tanel Mahlakõiv, Qian Ye, Srinivas Somanchi, Shuyang He, Hemlata Rana, Andrea DiFiglia, Joseph Gleason, William van der Touw, Robert Hariri, Xiaokui Zhang

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001975; DOI: 10.1136/jitc-2020-001975
Host response to immune checkpoint inhibitors contributes to tumor aggressiveness
Irina Khononov, Eyal Jacob, Ella Fremder, Nili Dahan, Michal Harel, Ziv Raviv, Boris Krastev, Yuval Shaked

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001996; DOI: 10.1136/jitc-2020-001996

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