Review ArticleReview Articles
A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang and Patrick Y. Wen
American Journal of Neuroradiology June 2024, ajnr.A8396; DOI: https://doi.org/10.3174/ajnr.A8396
Benjamin M. Ellingson
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Francesco Sanvito
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Timothy F. Cloughesy
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Raymond Y. Huang
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Javier E. Villanueva-Meyer
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Whitney B. Pope
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Daniel P. Barboriak
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Lalitha K. Shankar
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Marion Smits
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Timothy J. Kaufmann
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Jerrold L. Boxerman
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Michael Weller
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Evanthia Galanis
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
John de Groot
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Mark R. Gilbert
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Andrew B. Lassman
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Mark S. Shiroishi
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Ali Nabavizadeh
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Minesh Mehta
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Roger Stupp
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Wolfgang Wick
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
David A. Reardon
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Michael A. Vogelbaum
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Martin van den Bent
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Susan M. Chang
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
Patrick Y. Wen
From UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (BME, FS); UCLA Brain Tumor Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (TFC); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (RYH); Departments of Radiology and Neurosurgery, University of California San Francisco, CA (JEVM); Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (WBP); Department of Radiology, Duke University Medical Center, Durham, NC (DPB); Clinical Trials Branch, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD (LKS); Department of Radiology & Nuclear Medicine, Erasmus MC -University Medical Centre Rotterdam, Rotterdam, The Netherlands (MS); Department of Radiology, Mayo Clinic, Rochester, MN (TJK); Department of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI (JLB); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (MW); Department of Oncology, Mayo Clinic, Rochester, MN (EG); Division of Neuro-Oncology, Department of Neurosurgery, University of California, San Francisco, CA (JdG, SMC); Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (MRG); Division of Neuro-Oncology, Department of Neurology, Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY (ABL); Department of Radiology, Keck School of Medicine of the University of Southern California USC, Los Angeles, CA (MSS); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (AN); Miami Cancer Institute, Miami, FL (MM); Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology, Northwestern University, Chicago, IL (RS); Department of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology, German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany (WW); Center For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (DAR, PYW); Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL (MAV); Department Neuro-Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (MvdB).
ABSTRACT
Radiographic assessment plays a crucial role in the management of patients with central nervous system (CNS) tumors, aiding in treatment planning and evaluation of therapeutic efficacy by quantifying response. Recently, an updated version of the Response Assessment in Neuro-Oncology (RANO) criteria (RANO 2.0) was developed to improve upon prior criteria and provide an updated, standardized framework for assessing treatment response in clinical trials for gliomas in adults. This article provides an overview of significant updates to the criteria including (1) the use of a unified set of criteria for high and low grade gliomas in adults; (2) the use of the post-radiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas; (3) the option for the trial to mandate a confirmation scan to more reliably distinguish pseudoprogression from tumor progression; (4) the option of using volumetric tumor measurements; and (5) the removal of subjective non-enhancing tumor evaluations in predominantly enhancing gliomas (except for specific therapeutic modalities). Step-by-step pragmatic guidance is hereby provided for the neuroradiologist and imaging core lab involved in operationalization and technical execution of RANO 2.0 in clinical trials, including the display of representative cases and in-depth discussion of challenging scenarios.
ABBREVIATIONS: BTIP = Brain Tumor Imaging Protocol; CE = Contrast-Enhancing; CNS = Central Nervous System; CR = Complete Response; ECOG = Eastern Cooperative Oncology Group; HGG = High-Grade Glioma; IDH = Isocitrate Dehydrogenase; IRF = Independent Radiologic Facility; LGG = Low-Grade Glioma; KPS = Karnofsky Performance Status; MR = Minor Response; mRANO = Modified RANO; NANO = Neurological Assessment in Neuro-Oncology; ORR = Objective Response Rate; OS = Overall Survival; PD = Progressive Disease; PFS = Progression-Free Survival; PR = Partial Response; PsP = Pseudoprogression; RANO = Response Assessment in Neuro-Oncology; RECIST = Response Evaluation Criteria In Solid Tumors; RT = Radiation Therapy; SD = Stable Disease; Tx = Treatment.
Footnotes
The authors declare no conflicts of interest relative to the content of this article.
- © 2024 by American Journal of Neuroradiology
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Accepted Manuscript
Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang, Patrick Y. Wen
A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
American Journal of Neuroradiology Jun 2024, ajnr.A8396; DOI: 10.3174/ajnr.A8396
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Accepted Manuscript
A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang, Patrick Y. Wen
American Journal of Neuroradiology Jun 2024, ajnr.A8396; DOI: 10.3174/ajnr.A8396
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