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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Mesial Prefrontal Cortex Degeneration in Amyotrophic Lateral Sclerosis: A High-Field Proton MR Spectroscopy Study

U. Usman, C. Choi, R. Camicioli, P. Seres, M. Lynch, R. Sekhon, W. Johnston and S. Kalra
American Journal of Neuroradiology July 2011, DOI: https://doi.org/10.3174/ajnr.A2590
U. Usman
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C. Choi
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R. Camicioli
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P. Seres
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M. Lynch
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R. Sekhon
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W. Johnston
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S. Kalra
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Abstract

BACKGROUND AND PURPOSE: Frontotemporal lobar degeneration is responsible for the cognitive abnormalities seen in patients with ALS. We sought to evaluate the in vivo neurochemical changes associated with this pathology indicative of neuronal loss and gliosis.

MATERIALS AND METHODS: Twenty-four patients with ALS (2 with ALS-FTD) and 15 healthy controls were studied. High-field proton MR spectroscopy of the mesial prefrontal cortex was used to determine concentrations of NAA and mIns, markers of neuronal integrity and gliosis, respectively. Metabolite concentrations were correlated with cognitive tests (verbal fluency, ACE).

RESULTS: NAA/mIns was decreased 17% (P = .002). Abnormalities were present to a lesser degree in the individual metabolites NAA (decreased 9%; P = .08) and mIns (increased 11%; P = .06) than the ratio of the 2 metabolites. These measures did not correlate significantly with verbal fluency or the ACE.

CONCLUSIONS: Prefrontal lobe degeneration exists in patients with ALS as indicated by an abnormal mesial prefrontal cortex neurochemical profile. Further study is necessary to determine the potential utility of the NAA/mIns ratio as a biomarker for frontal lobe degeneration in ALS.

Footnotes

  • ACE
    Addenbrooke's Cognitive Examination
    ALS
    amyotrophic lateral sclerosis
    ALSFRS-R
    ALS Functional Rating Scale-Revised
    FTD
    frontotemporal dementia
    FTLD
    frontotemporal lobar degeneration
    MRS
    MR spectroscopy
    NAA
    N-acetylaspartate
    mIns
    myo-inositol
    PET
    positron-emission tomography
    PFC
    prefrontal cortex
    RF
    radio frequency
    TDP-43
    TAR DNA binding protein of 43 kDa

  • © 2011 American Society of Neuroradiology
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U. Usman, C. Choi, R. Camicioli, P. Seres, M. Lynch, R. Sekhon, W. Johnston, S. Kalra
Mesial Prefrontal Cortex Degeneration in Amyotrophic Lateral Sclerosis: A High-Field Proton MR Spectroscopy Study
American Journal of Neuroradiology Jul 2011, DOI: 10.3174/ajnr.A2590

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Mesial Prefrontal Cortex Degeneration in Amyotrophic Lateral Sclerosis: A High-Field Proton MR Spectroscopy Study
U. Usman, C. Choi, R. Camicioli, P. Seres, M. Lynch, R. Sekhon, W. Johnston, S. Kalra
American Journal of Neuroradiology Jul 2011, DOI: 10.3174/ajnr.A2590
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