IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

Russell K Pachynski; Chihiro Morishima; Russell Szmulewitz; Lauren Harshman; Leonard Appleman; Paul Monk; Rhonda L Bitting; Omer Kucuk; Frederick Millard; John D Seigne; Steven P Fling; Holden T Maecker; Caroline Duault; Nirasha Ramchurren; Bruce Hess; Leonard D’Amico; Andreanne Lacroix; Judith C Kaiser; Michel Morre; Anne Grégoire; Martin Cheever; Evan Y Yu; Lawrence Fong

doi:10.1136/jitc-2021-002903

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Clinical/translational cancer immunotherapy

Original research

IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

Authors

Russell K Pachynski Department of Medicine, Washington University School of Medicine, St Louis, MO, USA PubMed articles Google scholar articles
Chihiro Morishima University of Washington, Seattle, Washington, USA PubMed articles Google scholar articles
Russell Szmulewitz University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA PubMed articles Google scholar articles
Lauren Harshman Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA*Current affiliation: Surface Oncology, Cambridge, MA, USA PubMed articles Google scholar articles
Leonard Appleman UPMC, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Paul Monk Ohio State University James Cancer Hospital, Columbus, Ohio, USA PubMed articles Google scholar articles
Rhonda L Bitting Wake Forest Baptist Health, Winston-Salem, North Carolina, USA PubMed articles Google scholar articles
Omer Kucuk Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Frederick Millard University of California San Diego, La Jolla, California, USA PubMed articles Google scholar articles
John D Seigne Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA PubMed articles Google scholar articles
Steven P Fling Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Holden T Maecker Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA PubMed articles Google scholar articles
Caroline Duault Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA PubMed articles Google scholar articles
Nirasha Ramchurren Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Bruce Hess Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Leonard D’Amico Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Andreanne Lacroix Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Judith C Kaiser Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Michel Morre RevImmune, Paris, France PubMed articles Google scholar articles
Anne Grégoire RevImmune, Paris, France PubMed articles Google scholar articles
Martin Cheever Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Evan Y Yu University of Washington, Seattle, Washington, USAFred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Lawrence Fong University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles

Citation

Pachynski RK, Morishima C, Szmulewitz R, et al

IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

Journal for ImmunoTherapy of Cancer 2021;9:e002903. doi: 10.1136/jitc-2021-002903

Online issue publication

November 02, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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