Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab

James L Alexander; Hajir Ibraheim; Bhavisha Sheth; Jessica Little; Muhammad Saheb Khan; Camellia Richards; Nikki Hunter; Dharmisha Chauhan; Raguprakash Ratnakumaran; Kathleen McHugh; David J Pinato; Paul Nathan; Julia Choy; Shanthini M Crusz; Andrew Furness; Samra Turajlic; Lisa Pickering; James Larkin; Julian P Teare; Sophie Papa; Ally Speight; Anand Sharma; Nick Powell

doi:10.1136/jitc-2021-002742

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Clinical/translational cancer immunotherapy

Original research

Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab

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James L Alexander Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UKDepartment of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Hajir Ibraheim Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UKDepartment of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Bhavisha Sheth Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Jessica Little Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Muhammad Saheb Khan Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Camellia Richards Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK PubMed articles Google scholar articles
Nikki Hunter Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Dharmisha Chauhan Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Raguprakash Ratnakumaran Department of Clinical Oncology, Royal Surrey NHS Foundation Trust, Guildford, UK PubMed articles Google scholar articles
Kathleen McHugh Department of Gastroenterology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK PubMed articles Google scholar articles
David J Pinato Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, UKDepartment of Surgery & Cancer, Imperial College London, London, UK PubMed articles Google scholar articles
Paul Nathan Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK PubMed articles Google scholar articles
Julia Choy Medical Oncology, Barts Health NHS Trust, London, UK PubMed articles Google scholar articles
Shanthini M Crusz Medical Oncology, Barts Health NHS Trust, London, UK PubMed articles Google scholar articles
Andrew Furness Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Samra Turajlic Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UKTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK PubMed articles Google scholar articles
Lisa Pickering Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
James Larkin Department of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Julian P Teare Department of Surgery & Cancer, Imperial College London, London, UK PubMed articles Google scholar articles
Sophie Papa Medical Oncology, Guy's and Saint Thomas' NHS Foundation Trust, London, UKSchool of Cancer and Pharmaceutical Sciences, King's College London, London, UK PubMed articles Google scholar articles
Ally Speight Department of Gastroenterology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK PubMed articles Google scholar articles
Anand Sharma Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK PubMed articles Google scholar articles
Nick Powell Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UKDepartment of Medical Oncology, Royal Marsden NHS Foundation Trust, London, UK PubMed articles Google scholar articles

Citation

Alexander JL, Ibraheim H, Sheth B, et al

Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab

Journal for ImmunoTherapy of Cancer 2021;9:e002742. doi: 10.1136/jitc-2021-002742

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November 02, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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