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  • Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment

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Basic tumor immunology
Original research
Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment

Authors

  • Shota Aoyama Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USADepartment of Gastroenterology and General Surgery, Tokyo Women's Medical University, Shinjuku-ku, Japan PubMed articlesGoogle scholar articles
  • Ryosuke Nakagawa Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USADepartment of Gastroenterology and General Surgery, Tokyo Women's Medical University, Shinjuku-ku, Japan PubMed articlesGoogle scholar articles
  • Satoshi Nemoto Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USADepartment of Gastroenterology and General Surgery, Tokyo Women's Medical University, Shinjuku-ku, Japan PubMed articlesGoogle scholar articles
  • Patricio Perez-Villarroel Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • James J Mulé Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USACutaneous Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Adam William Mailloux Department of Microbiology and Immunology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA PubMed articlesGoogle scholar articles

Citation

Aoyama S, Nakagawa R, Nemoto S, et al
Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment
Journal for ImmunoTherapy of Cancer 2021;9:e002269. doi: 10.1136/jitc-2020-002269
Online issue publication 
February 24, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.