Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Erin F Simonds; Edbert D Lu; Oscar Badillo; Shokoufeh Karimi; Eric V Liu; Whitney Tamaki; Chiara Rancan; Kira M Downey; Jacob Stultz; Meenal Sinha; Lauren K McHenry; Nicole M Nasholm; Pavlina Chuntova; Anders Sundström; Vassilis Genoud; Shilpa A Shahani; Leo D Wang; Christine E Brown; Paul R Walker; Fredrik J Swartling; Lawrence Fong; Hideho Okada; William A Weiss; Mats Hellström

doi:10.1136/jitc-2020-002181

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Basic tumor immunology

Original research

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Authors

Erin F Simonds Department of Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Edbert D Lu Department of Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Oscar Badillo Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Shokoufeh Karimi Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Eric V Liu Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Whitney Tamaki Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Chiara Rancan Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Kira M Downey Department of Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Jacob Stultz Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Meenal Sinha Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Lauren K McHenry Department of Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Nicole M Nasholm Department of Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Pavlina Chuntova Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Anders Sundström Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Vassilis Genoud Translational Research Centre in Oncohaematology, Department of Medicine, University of Geneva, Geneva, Switzerland PubMed articles Google scholar articles
Shilpa A Shahani Department of Pediatrics, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Leo D Wang Department of Pediatrics, City of Hope National Medical Center, Duarte, California, USADepartment of Immuno-Oncology, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Christine E Brown Departments of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte CA, Duarte, California, USA PubMed articles Google scholar articles
Paul R Walker Translational Research Centre in Oncohaematology, Department of Medicine, University of Geneva, Geneva, Switzerland PubMed articles Google scholar articles
Fredrik J Swartling Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Lawrence Fong Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, USAParker Institute for Cancer Immunotherapy, San Francisco, California, USA PubMed articles Google scholar articles
Hideho Okada Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USAParker Institute for Cancer Immunotherapy, San Francisco, California, USA PubMed articles Google scholar articles
William A Weiss Parker Institute for Cancer Immunotherapy, San Francisco, California, USADepartments of Neurology, Neurological Surgery, and Pediatrics, University of California San Francisco, San Francisco, California, USAHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Mats Hellström Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles

Citation

Simonds EF, Lu ED, Badillo O, et al

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Journal for ImmunoTherapy of Cancer 2021;9:e002181. doi: 10.1136/jitc-2020-002181

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February 24, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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