Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma

Chantal Saberian; Rodabe N. Amaria; Amer M. Najjar; Laszlo G. Radvanyi; Cara L. Haymaker; Marie-Andrée Forget; Roland L. Bassett; Silvana C. Faria; Isabella C. Glitza; Enrique Alvarez; Sapna Parshottam; Victor Prieto; Gregory Lizée; Michael K. Wong; Jennifer L. McQuade; Adi Diab; Cassian Yee; Hussein A. Tawbi; Sapna Patel; Elizabeth J. Shpall; Michael A. Davies; Patrick Hwu; Chantale Bernatchez

doi:10.1136/jitc-2021-002449

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Clinical/translational cancer immunotherapy

Original research

Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma

Authors

Chantal Saberian Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Rodabe N. Amaria Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Amer M. Najjar Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA PubMed articles Google scholar articles
Laszlo G. Radvanyi Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAOntario Institute for Cancer Research, Ontario, Ontario, Canada PubMed articles Google scholar articles
Cara L. Haymaker Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, USA PubMed articles Google scholar articles
Marie-Andrée Forget Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Roland L. Bassett Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Silvana C. Faria Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Isabella C. Glitza Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Enrique Alvarez Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Sapna Parshottam Department of Biologics Development, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Victor Prieto Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Gregory Lizée Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Michael K. Wong Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jennifer L. McQuade Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Adi Diab Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Cassian Yee Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Hussein A. Tawbi Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Sapna Patel Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Elizabeth J. Shpall Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Michael A. Davies Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Patrick Hwu Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Chantale Bernatchez Melanoma Medical Onoclogy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Biologics Development, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles

Citation

Saberian C, Amaria RN, Najjar AM, et al

Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma

Journal for ImmunoTherapy of Cancer 2021;9:e002449. doi: 10.1136/jitc-2021-002449

Online issue publication

February 07, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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