Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Michael W Knitz; Thomas E Bickett; Laurel B Darragh; Ayman J Oweida; Shilpa Bhatia; Benjamin Van Court; Shiv Bhuvane; Miles Piper; Jacob Gadwa; Adam C Mueller; Diemmy Nguyen; Varuna Nangia; Douglas G Osborne; Xiyuan Bai; Sarah E Ferrara; Mary-Keara Boss; Andrew Goodspeed; Matthew A Burchill; Beth A Jirón Tamburini; Edward D Chan; Curtis R Pickering; Eric T Clambey; Sana D Karam

doi:10.1136/jitc-2020-001955

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Clinical/translational cancer immunotherapy

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Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

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Michael W Knitz Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Thomas E Bickett Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Laurel B Darragh Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Ayman J Oweida Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, Quebec, Canada PubMed articles Google scholar articles
Shilpa Bhatia Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Benjamin Van Court Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Shiv Bhuvane Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Miles Piper Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Jacob Gadwa Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Adam C Mueller Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Diemmy Nguyen Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Varuna Nangia Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Douglas G Osborne Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Xiyuan Bai Department of Academic Affairs, National Jewish Health, Denver, Colorado, USA PubMed articles Google scholar articles
Sarah E Ferrara University of Colorado Comprehensive Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Mary-Keara Boss Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA PubMed articles Google scholar articles
Andrew Goodspeed University of Colorado Comprehensive Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Matthew A Burchill Division of Gastroenterology & Hepatology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Beth A Jirón Tamburini Division of Gastroenterology & Hepatology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Edward D Chan Department of Academic Affairs, National Jewish Health, Denver, Colorado, USA PubMed articles Google scholar articles
Curtis R Pickering Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Eric T Clambey Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles
Sana D Karam Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA PubMed articles Google scholar articles

Citation

Knitz MW, Bickett TE, Darragh LB, et al

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Journal for ImmunoTherapy of Cancer 2021;9:e001955. doi: 10.1136/jitc-2020-001955

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May 06, 2021

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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