Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Siyuan Dai; Han Zeng; Zhaopei Liu; Kaifeng Jin; Wenbin Jiang; Zewei Wang; Zhiyuan Lin; Ying Xiong; Jiajun Wang; Yuan Chang; Qi Bai; Yu Xia; Li Liu; Yu Zhu; Le Xu; Yang Qu; Jianming Guo; Jiejie Xu

doi:10.1136/jitc-2020-001823

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Immunotherapy biomarkers

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Intratumoral CXCL13⁺CD8⁺T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

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Siyuan Dai Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Han Zeng Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China PubMed articles Google scholar articles
Zhaopei Liu Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China PubMed articles Google scholar articles
Kaifeng Jin Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China PubMed articles Google scholar articles
Wenbin Jiang Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Zewei Wang Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Zhiyuan Lin Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Ying Xiong Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Jiajun Wang Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Yuan Chang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China PubMed articles Google scholar articles
Qi Bai Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Yu Xia Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Li Liu Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Yu Zhu Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China PubMed articles Google scholar articles
Le Xu Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articles Google scholar articles
Yang Qu Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Jiejie Xu Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China PubMed articles Google scholar articles

Citation

Dai S, Zeng H, Liu Z, et al

Intratumoral CXCL13⁺CD8⁺T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer 2021;9:e001823. doi: 10.1136/jitc-2020-001823

Online issue publication

January 26, 2023

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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