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  • Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

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Immunotherapy biomarkers
Original research
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Authors

  • Helena Van Damme Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Bruno Dombrecht VIB Discovery Sciences, VIB, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Máté Kiss Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Heleen Roose Oncurious NV, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Elizabeth Allen Oncurious NV, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Eva Van Overmeire Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Daliya Kancheva Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Liesbet Martens VIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Aleksandar Murgaski Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Pauline Madeleine Rachel Bardet Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Gillian Blancke Department of Internal Medicine and Pediatrics, Ghent University, Ghent, BelgiumHost-Microbiota-Interaction Lab (HMI), VIB-UGent Center for Inflammation Research, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Maude Jans Department of Internal Medicine and Pediatrics, Ghent University, Ghent, BelgiumHost-Microbiota-Interaction Lab (HMI), VIB-UGent Center for Inflammation Research, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Evangelia Bolli Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Maria Solange Martins Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Yvon Elkrim Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • James Dooley Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, Cambridgeshire, UK PubMed articlesGoogle scholar articles
  • Louis Boon Polpharma Biologics, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Julia Katharina Schwarze Department of Medical Oncology, UZ Brussel, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Frank Tacke Department of Medicine III, RWTH Aachen University, Aachen, Nordrhein-Westfalen, Germany PubMed articlesGoogle scholar articles
  • Kiavash Movahedi Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Niels Vandamme Data Mining and Modelling for Biomedicine, VIB-UGent Center for Inflammation Research, Ghent, BelgiumDepartment of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Bart Neyns Department of Medical Oncology, UZ Brussel, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Sebahat Ocak Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL et Dermatologie (PNEU), UCLouvain, Louvain-la-Neuve, BelgiumDivision of Pneumology, CHU UCL Namur, Yvoir, Namur, Belgium PubMed articlesGoogle scholar articles
  • Isabelle Scheyltjens Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Lars Vereecke Department of Internal Medicine and Pediatrics, Ghent University, Ghent, BelgiumHost-Microbiota-Interaction Lab (HMI), VIB-UGent Center for Inflammation Research, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Frank Aboubakar Nana Division of Pneumology, CHU UCL Namur, Yvoir, Namur, BelgiumDivision of Pneumology, Cliniques universitaires Saint-Luc, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Pascal Merchiers Oncurious NV, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Damya Laoui Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Jo Agnes Van Ginderachter Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, BelgiumMyeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium PubMed articlesGoogle scholar articles

Citation

Van Damme H, Dombrecht B, Kiss M, et al
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
Journal for ImmunoTherapy of Cancer 2021;9:e001749. doi: 10.1136/jitc-2020-001749
Online issue publication 
January 26, 2023

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.