Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study

Marc Oliva; Douglas Chepeha; Daniel V Araujo; J. Javier Diaz-Mejia; Peter Olson; Amy Prawira; Anna Spreafico; Scott V Bratman; Tina Shek; John de Almeida; Aaron R Hansen; Andrew Hope; David Goldstein; Ilan Weinreb; Stephen Smith; Bayardo Perez-Ordoñez; Jonathan Irish; Dax Torti; Jeffrey P. Bruce; Ben X. Wang; Anthony Fortuna; Trevor J. Pugh; Hirak Der-Torossian; Ronald Shazer; Nickolas Attanasio; Qingyan Au; Antony Tin; Jordan Feeney; Himanshu Sethi; Alexey Aleshin; Isan Chen; Lillian Siu

doi:10.1136/jitc-2021-003476

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Clinical/translational cancer immunotherapy

Original research

Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study

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Marc Oliva Department of Medical Oncology, Institut Catala d’ Oncologia, L’Hospitalet de Llobregat, Barcelona, SpainDivision of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Douglas Chepeha Department of Otolaryngology and Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Daniel V Araujo Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, CanadaDivision of Medical Oncology, Hospital de Base São Jose do Rio Preto, Sao Paulo, Brazil PubMed articles Google scholar articles
J. Javier Diaz-Mejia Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Peter Olson Department of Research, Mirati Therapeutics, San Diego, California, USA PubMed articles Google scholar articles
Amy Prawira Department of Medical Oncology, The Kinghorn Cancer Centre, St Vincent’s Hospital, Sidney, New South Wales, Australia PubMed articles Google scholar articles
Anna Spreafico Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Scott V Bratman Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, CanadaDepartment of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Tina Shek Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
John de Almeida Department of Otolaryngology and Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Aaron R Hansen Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Andrew Hope Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, CanadaDepartment of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
David Goldstein Department of Otolaryngology and Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Ilan Weinreb Department of Pathology, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Stephen Smith Department of Pathology, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Bayardo Perez-Ordoñez Department of Pathology, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Jonathan Irish Department of Otolaryngology and Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Dax Torti Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, CanadaOntario Institute for Cancer Research, Toronto, Ontario, Canada PubMed articles Google scholar articles
Jeffrey P. Bruce Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Ben X. Wang Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, CanadaDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Anthony Fortuna Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Trevor J. Pugh Tumor Immunotherapy Program, Princess Margaret Cancer Centre, Toronto, Ontario, CanadaOntario Institute for Cancer Research, Toronto, Ontario, CanadaDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Hirak Der-Torossian Clinical Development, Mirati Therapeutics, San Diego, California, USA PubMed articles Google scholar articles
Ronald Shazer Clinical Development, Mirati Therapeutics, San Diego, California, USA PubMed articles Google scholar articles
Nickolas Attanasio Neogenomics Laboratories, Fort Myers, Florida, USA PubMed articles Google scholar articles
Qingyan Au Neogenomics Laboratories, Fort Myers, Florida, USA PubMed articles Google scholar articles
Antony Tin Natera Inc, San Carlos, California, USA PubMed articles Google scholar articles
Jordan Feeney Natera Inc, San Carlos, California, USA PubMed articles Google scholar articles
Himanshu Sethi Natera Inc, San Carlos, California, USA PubMed articles Google scholar articles
Alexey Aleshin Natera Inc, San Carlos, California, USA PubMed articles Google scholar articles
Isan Chen Clinical Development, Mirati Therapeutics, San Diego, California, USA PubMed articles Google scholar articles
Lillian Siu Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles

Citation

Oliva M, Chepeha D, Araujo DV, et al

Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study

Journal for ImmunoTherapy of Cancer 2021;9:e003476. doi: 10.1136/jitc-2021-003476

Online issue publication

June 27, 2023

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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