Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

Dan You; Stephen Hillerman; Gregory Locke; Charu Chaudhry; Caitlyn Stromko; Anwar Murtaza; Yi Fan; Jennifer Koenitzer; Yali Chen; Stephanie Briceno; Rajarshi Bhadra; Elizabeth Duperret; Johnni Gullo-Brown; Chan Gao; Dandan Zhao; John Feder; Joshua Curtin; Andrew P Degnan; Godwin Kumi; Mark Wittman; Benjamin M Johnson; Karen E Parrish; Giridharan Gokulrangan; John Morrison; Michael Quigley; John T Hunt; Luisa Salter-Cid; Emma Lees; Miguel A Sanjuan; Jinqi Liu

doi:10.1136/jitc-2020-001402

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Basic tumor immunology

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Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

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Dan You Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Stephen Hillerman Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Gregory Locke Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Charu Chaudhry Oncology Discovery, Johnson and Johnson Limited, Spring House, Pennsylvania, USA PubMed articles Google scholar articles
Caitlyn Stromko Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Anwar Murtaza Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Yi Fan Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Jennifer Koenitzer Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Yali Chen Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Stephanie Briceno Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Rajarshi Bhadra Oncology Discovery, Pfizer Inc, San Diego, California, USA PubMed articles Google scholar articles
Elizabeth Duperret Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Johnni Gullo-Brown Oncology Discovery, Pfizer Inc, San Diego, California, USA PubMed articles Google scholar articles
Chan Gao Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Dandan Zhao Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
John Feder Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Joshua Curtin Oncology Discovery, Johnson and Johnson Limited, Spring House, Pennsylvania, USA PubMed articles Google scholar articles
Andrew P Degnan Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Godwin Kumi Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Mark Wittman Oncology Discovery, Bristol-Myers Squibb Co, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Benjamin M Johnson Oncology Discovery, Bristol-Myers Squibb Co, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Karen E Parrish Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Giridharan Gokulrangan Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
John Morrison Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Michael Quigley Oncology Discovery, Gilead Sciences Inc, Foster City, California, USA PubMed articles Google scholar articles
John T Hunt Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Luisa Salter-Cid Oncology Discovery, Gossamer Bio, San Diego, California, USA PubMed articles Google scholar articles
Emma Lees Oncology Discovery, Bristol-Myers Squibb Co, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Miguel A Sanjuan Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles
Jinqi Liu Oncology Discovery, Bristol-Myers Squibb Co, Princeton, New Jersey, USA PubMed articles Google scholar articles

Citation

You D, Hillerman S, Locke G, et al

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

Journal for ImmunoTherapy of Cancer 2021;9:e001402. doi: 10.1136/jitc-2020-001402

Online issue publication

November 23, 2023

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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