439 Dual modes of action for anti-TIM-3 antibody MBG453 in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): preclinical evidence for immune-mediated and anti-leukemic activity

Catherine Sabatos-Peyton; Tyler Longmire; Lisa Baker; Nidhi Patel; Anne-Sophie Wavreille; Melanie Verneret; Pushpa Jayaraman; Xiaomo Jiang; Stephanie Schwartz; Viviana Cremasco; Hongbo Lu; Shumei Qiu; Fiona Sharp; Mikael Rinne; Glenn Dranoff

doi:10.1136/jitc-2020-SITC2020.0439

Article info

Regular and young investigator award abstracts

Combination immunotherapies

439 Dual modes of action for anti-TIM-3 antibody MBG453 in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): preclinical evidence for immune-mediated and anti-leukemic activity

Authors

Catherine Sabatos-Peyton Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Tyler Longmire Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Lisa Baker Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Nidhi Patel Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Anne-Sophie Wavreille Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Melanie Verneret Novartis, Basel, Switzerland PubMed articles Google scholar articles
Pushpa Jayaraman Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Xiaomo Jiang Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Stephanie Schwartz Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Viviana Cremasco Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Hongbo Lu Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Shumei Qiu Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Fiona Sharp Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Mikael Rinne Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles
Glenn Dranoff Novartis Institute of BioMedical Research, Inc, Cambridge, MA, USA PubMed articles Google scholar articles

Citation

Sabatos-Peyton C, Longmire T, Baker L, et al

439 Dual modes of action for anti-TIM-3 antibody MBG453 in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): preclinical evidence for immune-mediated and anti-leukemic activity

Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0439

Online issue publication

December 12, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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