Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy

Chia-Sing Lu; Ching-Wen Lin; Ya-Hsuan Chang; Hsuan-Yu Chen; Wei-Chia Chung; Wei-Yun Lai; Chao-Chi Ho; Tong-Hong Wang; Chi-Yuan Chen; Chen-Lin Yeh; Sean Wu; Shu-Ping Wang; Pan-Chyr Yang

doi:10.1136/jitc-2020-001392

Article info

PDF

PDF +
Supplementary
Material

XML

Basic tumor immunology

Original research

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy

Authors

Chia-Sing Lu Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan PubMed articles Google scholar articles
Ching-Wen Lin Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Ya-Hsuan Chang Institute of Statistical Science, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Hsuan-Yu Chen Institute of Statistical Science, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Wei-Chia Chung Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Wei-Yun Lai Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Chao-Chi Ho Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan PubMed articles Google scholar articles
Tong-Hong Wang Tissue Bank, Chang Gung Memorial Hospital; Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan PubMed articles Google scholar articles
Chi-Yuan Chen Tissue Bank, Chang Gung Memorial Hospital; Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan PubMed articles Google scholar articles
Chen-Lin Yeh Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan PubMed articles Google scholar articles
Sean Wu Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Shu-Ping Wang Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Pan-Chyr Yang Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Institute of Biomedical Sciences and Genomics Research Center, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles

Citation

Lu C, Lin C, Chang Y, et al

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy

Journal for ImmunoTherapy of Cancer 2020;8:e001392. doi: 10.1136/jitc-2020-001392

Online issue publication

November 26, 2020

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password