Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

Sean J Judge; Morgan A Darrow; Steve W Thorpe; Alicia A Gingrich; Edmond F O'Donnell; Alyssa R Bellini; Ian R Sturgill; Logan V Vick; Cordelia Dunai; Kevin M Stoffel; Yue Lyu; Shuai Chen; May Cho; Robert B Rebhun; Arta M Monjazeb; William J Murphy; Robert J Canter

doi:10.1136/jitc-2020-001355

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Clinical/translational cancer immunotherapy

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Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

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Sean J Judge Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Morgan A Darrow Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Steve W Thorpe Orthopedic Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Alicia A Gingrich Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Edmond F O'Donnell Orthopedic Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Alyssa R Bellini Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Ian R Sturgill Dermatology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Logan V Vick Dermatology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Cordelia Dunai Dermatology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Kevin M Stoffel Dermatology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Yue Lyu Statistics, University of California Davis, Davis, California, USA PubMed articles Google scholar articles
Shuai Chen Public Health Sciences, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
May Cho Internal Medicine, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Robert B Rebhun Center for Companion Animal Health, Department of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, California, USA PubMed articles Google scholar articles
Arta M Monjazeb Radiation Oncology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
William J Murphy Dermatology, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles
Robert J Canter Surgery, University of California Davis School of Medicine, Sacramento, California, USA PubMed articles Google scholar articles

Citation

Judge SJ, Darrow MA, Thorpe SW, et al

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

Journal for ImmunoTherapy of Cancer 2020;8:e001355. doi: 10.1136/jitc-2020-001355

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November 06, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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