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  • Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia

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Clinical/translational cancer immunotherapy
Original research
Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia

Authors

  • Pinar Ataca Atilla Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Mary K McKenna Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Haruko Tashiro Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Madhuwanti Srinivasan Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Feiyan Mo Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Norihiro Watanabe Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Brian Wesley Simons Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Alexandra McLean Stevens Division of Pediatric Hematology/Oncology, Texas Children's Hospital, Houston, Texas, USA Division of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Michele S Redell Division of Pediatric Hematology/Oncology, Texas Children's Hospital, Houston, Texas, USA Division of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Helen E Heslop Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas, USA Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA Department of Medicine, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Maksim Mamonkin Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Malcolm K Brenner Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas, USA Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA Department of Medicine, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles
  • Erden Atilla Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA PubMed articlesGoogle scholar articles

Citation

Ataca Atilla P, McKenna MK, Tashiro H, et al
Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia
Journal for ImmunoTherapy of Cancer 2020;8:e001229. doi: 10.1136/jitc-2020-001229
Online issue publication 
September 16, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.