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  • PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer

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Clinical/translational cancer immunotherapy
Original research
PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer

Authors

  • Hannah S Newton Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Vaibhavkumar S Gawali Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Ameet A Chimote Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Maria A Lehn Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Sarah M Palackdharry Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Benjamin H Hinrichs Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Roman Jandarov Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • David Hildeman Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Edith M Janssen Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Trisha M Wise-Draper Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Laura Conforti Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles

Citation

Newton HS, Gawali VS, Chimote AA, et al
PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer
Journal for ImmunoTherapy of Cancer 2020;8:e000844. doi: 10.1136/jitc-2020-000844
Online issue publication 
October 15, 2020

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Copyright information

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.