Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

Kyle G Mitchell; Lixia Diao; Tatiana Karpinets; Marcelo V Negrao; Hai T Tran; Edwin R Parra; Erin M Corsini; Alexandre Reuben; Lorenzo Federico; Chantale Bernatchez; Hitoshi Dejima; Alejandro Francisco-Cruz; Jing Wang; Mara B Antonoff; Ara A Vaporciyan; Stephen G Swisher; Tina Cascone; Ignacio I Wistuba; John V Heymach; Don L Gibbons; Jianjun Zhang; Cara L Haymaker; Boris Sepesi

doi:10.1136/jitc-2019-000405

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Immunotherapy biomarkers

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Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

Authors

Kyle G Mitchell Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Lixia Diao Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Tatiana Karpinets Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Marcelo V Negrao Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Hai T Tran Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Edwin R Parra Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Erin M Corsini Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Alexandre Reuben Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Lorenzo Federico Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Chantale Bernatchez Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Hitoshi Dejima Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Alejandro Francisco-Cruz Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jing Wang Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Mara B Antonoff Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Ara A Vaporciyan Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Stephen G Swisher Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Tina Cascone Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Ignacio I Wistuba Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
John V Heymach Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Don L Gibbons Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jianjun Zhang Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Cara L Haymaker Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Boris Sepesi Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles

Citation

Mitchell KG, Diao L, Karpinets T, et al

Journal for ImmunoTherapy of Cancer 2020;8:e000405. doi: 10.1136/jitc-2019-000405

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January 11, 2022

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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