MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

Victor H Engelhard; Rebecca C Obeng; Kara L Cummings; Gina R Petroni; Angela L Ambakhutwala; Kimberly A Chianese-Bullock; Kelly T Smith; Amanda Lulu; Nikole Varhegyi; Mark E Smolkin; Paisley Myers; Keira E Mahoney; Jeffrey Shabanowitz; Nico Buettner; Emily H Hall; Kathleen Haden; Mark Cobbold; Donald F Hunt; Geoffrey Weiss; Elizabeth Gaughan; Craig L Slingluff, Jr

doi:10.1136/jitc-2019-000262

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Clinical/translational cancer immunotherapy

Original research

MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

Authors

Victor H Engelhard Beirne Carter Center for Immunology Research and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Rebecca C Obeng Beirne Carter Center for Immunology Research and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Kara L Cummings Beirne Carter Center for Immunology Research and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Gina R Petroni Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Angela L Ambakhutwala Beirne Carter Center for Immunology Research and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Kimberly A Chianese-Bullock Department of Surgery/Division of Surgical Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Kelly T Smith Department of Surgery/Division of Surgical Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Amanda Lulu Beirne Carter Center for Immunology Research and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Nikole Varhegyi Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Mark E Smolkin Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Paisley Myers Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Keira E Mahoney Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Jeffrey Shabanowitz Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Nico Buettner 7Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK PubMed articles Google scholar articles
Emily H Hall Office of Clinical Research, University Virginia Cancer Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Kathleen Haden Department of Surgery/Division of Surgical Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Mark Cobbold 7Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK PubMed articles Google scholar articles
Donald F Hunt Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Geoffrey Weiss Medicine/Division of Hematology-Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Elizabeth Gaughan Medicine/Division of Hematology-Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Craig L Slingluff, Jr Department of Surgery/Division of Surgical Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA PubMed articles Google scholar articles

Citation

Engelhard VH, Obeng RC, Cummings KL, et al

MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

Journal for ImmunoTherapy of Cancer 2020;8:e000262. doi: 10.1136/jitc-2019-000262

Online issue publication

January 11, 2022

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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