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  • Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

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Research Article
Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

Authors

  • A. M. Heeren Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • J. Rotman Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • A. G. M. Stam Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • N. Pocorni Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • A. A. Gassama Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • S. Samuels Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • M. C. G. Bleeker Department of PathologyAmsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • C. H. Mom Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • H. J. M. A. A. Zijlmans Center for Gynecologic Oncology Amsterdam (CGOA)The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • G. G. Kenter Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands Center for Gynecologic Oncology Amsterdam (CGOA)The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • E. S. Jordanova Center for Gynecologic Oncology Amsterdam (CGOA)Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam The Netherlands PubMed articlesGoogle scholar articles
  • T. D. de Gruijl Department of Medical OncologyAmsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam De Boelelaan 1117 1081 HV Amsterdam The Netherlands PubMed articlesGoogle scholar articles

Citation

Heeren AM, Rotman J, Stam AGM, et al
Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels
Journal for ImmunoTherapy of Cancer 2019;7:43. doi: 10.1186/s40425-019-0526-z
Online issue publication 
January 08, 2022

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© The Author(s). Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.