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  • Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

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Research Article
Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

Authors

  • Chang-Yu Chen Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Satoshi Ueha Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Yoshiro Ishiwata Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Shoji Yokochi Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • De Yang Cancer and Inflammation Program, Center for Cancer ResearchNational Cancer Institute at Frederick Frederick MD USA PubMed articlesGoogle scholar articles
  • Joost J. Oppenheim Cancer and Inflammation Program, Center for Cancer ResearchNational Cancer Institute at Frederick Frederick MD USA PubMed articlesGoogle scholar articles
  • Haru Ogiwara Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Shigeyuki Shichino Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Shungo Deshimaru Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Francis H. W. Shand Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles
  • Shiro Shibayama Research Center of ImmunologyTsukuba Institute, ONO Pharmaceutical Co., Ltd. Tsukuba Japan PubMed articlesGoogle scholar articles
  • Kouji Matsushima Division of Molecular Regulation of Inflammatory and Immune DiseasesResearch Institute for Biomedical Sciences, Tokyo University of Science Chiba Japan Department of Molecular Preventive Medicine, Graduate School of MedicineThe University of Tokyo Tokyo Japan PubMed articlesGoogle scholar articles

Citation

Chen C, Ueha S, Ishiwata Y, et al
Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice
Journal for ImmunoTherapy of Cancer 2019;7:21. doi: 10.1186/s40425-019-0503-6
Online issue publication 
January 08, 2022

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© The Author(s). Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.