CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Reyes Gonzalez-Exposito; Maria Semiannikova; Beatrice Griffiths; Khurum Khan; Louise J. Barber; Andrew Woolston; Georgia Spain; Katharina von Loga; Ben Challoner; Radhika Patel; Michael Ranes; Amanda Swain; Janet Thomas; Annette Bryant; Claire Saffery; Nicos Fotiadis; Sebastian Guettler; David Mansfield; Alan Melcher; Thomas Powles; Sheela Rao; David Watkins; Ian Chau; Nik Matthews; Fredrik Wallberg; Naureen Starling; David Cunningham; Marco Gerlinger

doi:10.1186/s40425-019-0575-3

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Research Article

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

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