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At 7T, 2D multiecho spin-echo T2WI and 3D gradient-echo T2*WI were acquired from 27 formalin-fixed coronal hemispheric brain sections of 15 patients and 4 healthy controls. Proteolipid-stained tissue sections were matched to the corresponding MR images, and lesions were manually scored on both MR imaging sequences and tissue sections. The T2WI sequence detected slightly more lesions than the T2*WI sequence (28% and 16%). When histopathologic information (type, location) was revealed to the reader, the sensitivity went up to 84%. Many lesions are still missed prospectively.