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Research ArticleBRAIN

Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla

A. Kangarlu, E.C. Bourekas, A. Ray-Chaudhury and K.W. Rammohan
American Journal of Neuroradiology February 2007, 28 (2) 262-266;
A. Kangarlu
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E.C. Bourekas
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A. Ray-Chaudhury
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K.W. Rammohan
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Abstract

BACKGROUND AND PURPOSE: Conventional imaging of ex-vivo brain at 1.5T in multiple sclerosis (MS) detects only a small fraction of the gray matter cerebral cortical lesions that can be detected by pathology. Our purpose was to examine if imaging at 8T can detect plaques in cortical gray matter (CGM) not evident at 1.5T.

METHODS: An ex-vivo brain obtained at autopsy from a patient with MS was formalin fixed and 1 cm coronal slices were examined using MR imaging at 8T.

RESULTS: Numerous cerebral cortical lesions not evident at 1.5T were seen at 8T. Lesions were easily identified using gradient-echo and spin-echo (SE) as well as diffusion images. MR imaging at 8T identified many of the types of plaques previously evident only by pathology. The magnitude of the cortical involvement in this 1 patient was severe. Lesions in the gray matter readily visible by high-field MR imaging were sometimes barely visible by pathology. MR imaging at 8T often facilitated the detection of such plaques by pathology.

CONCLUSION: This study establishes the utility of high-field imaging at 8T in the delineation of plaques in the cerebral CGM in MS.

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American Journal of Neuroradiology: 28 (2)
American Journal of Neuroradiology
Vol. 28, Issue 2
February 2007
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Cite this article
A. Kangarlu, E.C. Bourekas, A. Ray-Chaudhury, K.W. Rammohan
Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla
American Journal of Neuroradiology Feb 2007, 28 (2) 262-266;

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Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla
A. Kangarlu, E.C. Bourekas, A. Ray-Chaudhury, K.W. Rammohan
American Journal of Neuroradiology Feb 2007, 28 (2) 262-266;
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Cited By...

  • Imaging cortical multiple sclerosis lesions with ultra-high field MRI
  • Ultra-high-field MR imaging in multiple sclerosis
  • Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging
  • Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency: The Neuroimaging Perspective
  • MR Imaging of Gray Matter Involvement in Multiple Sclerosis: Implications for Understanding Disease Pathophysiology and Monitoring Treatment Efficacy
  • First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T
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