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  • ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

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Basic tumor immunology
Original research
ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

Authors

  • Tao Chen Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Jiangang Liu Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Chenci Wang Department of Oncology, Funan County People's Hospital, Fuyang, Anhui, China PubMed articlesGoogle scholar articles
  • Zhengwei Wang Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People's Republic of China PubMed articlesGoogle scholar articles
  • Jiayi Zhou Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, Guangdong, China PubMed articlesGoogle scholar articles
  • Jiani Lin Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Jie Mao Department of Neurosurgery, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China PubMed articlesGoogle scholar articles
  • Tingzheng Pan Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Jianwei Wang Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Hongchao Xu Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Xiaosheng He Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Dinglan Wu Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles
  • Zhuohao Liu Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, People's Republic of ChinaThe Third School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong, People's Republic of China PubMed articlesGoogle scholar articles

Citation

Chen T, Liu J, Wang C, et al
ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages
Journal for ImmunoTherapy of Cancer 2024;12:e009492. doi: 10.1136/jitc-2024-009492
Online issue publication 
August 13, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.