Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling

Edward Armstrong; Matthew K L Chiu; Shane Foo; Lizzie Appleton; Pablo Nenclares; Anton Patrikeev; Nitya Mohan; Martin Mclaughlin; Galabina Bozhanova; Julia Hoebart; Victoria Roulstone; Emmanuel Patin; Malin Pedersen; Joan Kyula; Masahiro Ono; Fiona Errington-Mais; John Bell; Kevin J Harrington; Alan Melcher; Victoria Jennings

doi:10.1136/jitc-2024-009443

Article info

Oncolytic and local immunotherapy

Original research

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling

Authors

Edward Armstrong Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Matthew K L Chiu Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKDepartment of Clinical Oncology, University of Hong Kong Faculty of Medicine, Hong Kong, Hong Kong PubMed articles Google scholar articles
Shane Foo Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Lizzie Appleton Imperial College London, London, London, UKThe Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Pablo Nenclares Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKHead and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Anton Patrikeev Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Nitya Mohan Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Martin Mclaughlin Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Galabina Bozhanova Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Julia Hoebart Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Victoria Roulstone The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Emmanuel Patin The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Malin Pedersen Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Joan Kyula The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Masahiro Ono Imperial College London, London, London, UK PubMed articles Google scholar articles
Fiona Errington-Mais Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK PubMed articles Google scholar articles
John Bell Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada PubMed articles Google scholar articles
Kevin J Harrington Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Alan Melcher Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Victoria Jennings Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKLeeds Institute of Medical Research, University of Leeds, Leeds, UK PubMed articles Google scholar articles

Citation

Armstrong E, Chiu MKL, Foo S, et al

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling

Journal for ImmunoTherapy of Cancer 2024;12:e009443. doi: 10.1136/jitc-2024-009443

Online issue publication

July 25, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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