Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers

You Zhang; Min Cao; Yanfei Wu; Sara Malih; Dong Xu; Erpeng Yang; Muhsin H Younis; Wilson Lin; Haitao Zhao; Cheng Wang; Qiufang Liu; Jonathan W Engle; Mohammad J Rasaee; Yihui Guan; Gang Huang; Jianjun Liu; Weibo Cai; Fang Xie; Weijun Wei

doi:10.1136/jitc-2024-008794

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Immunotherapy biomarkers

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Preclinical development of novel PD-L1 tracers and first-in-human study of [⁶⁸Ga]Ga-NOTA-RW102 in patients with lung cancers

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You Zhang Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Min Cao Department of Thoracic Surgery，Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Yanfei Wu Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Sara Malih Departments of Radiology and Medical Physics, University of Wisconsin−Madison, Madison, Wisconsin, USADepartment of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran PubMed articles Google scholar articles
Dong Xu Department of Thoracic Surgery, Huashan Hospital Fudan University, Shanghai, China PubMed articles Google scholar articles
Erpeng Yang Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Muhsin H Younis Departments of Radiology and Medical Physics, University of Wisconsin−Madison, Madison, Wisconsin, USA PubMed articles Google scholar articles
Wilson Lin Departments of Radiology and Medical Physics, University of Wisconsin−Madison, Madison, Wisconsin, USA PubMed articles Google scholar articles
Haitao Zhao Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Cheng Wang Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Qiufang Liu Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China PubMed articles Google scholar articles
Jonathan W Engle Departments of Radiology and Medical Physics, University of Wisconsin−Madison, Madison, Wisconsin, USA PubMed articles Google scholar articles
Mohammad J Rasaee Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran PubMed articles Google scholar articles
Yihui Guan Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Gang Huang Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Jianjun Liu Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Weibo Cai Departments of Radiology and Medical Physics, University of Wisconsin−Madison, Madison, Wisconsin, USA PubMed articles Google scholar articles
Fang Xie Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China PubMed articles Google scholar articles
Weijun Wei Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles

Citation

Zhang Y, Cao M, Wu Y, et al

Preclinical development of novel PD-L1 tracers and first-in-human study of [⁶⁸Ga]Ga-NOTA-RW102 in patients with lung cancers

Journal for ImmunoTherapy of Cancer 2024;12:e008794. doi: 10.1136/jitc-2024-008794

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April 05, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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