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Original research
Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and late-phase clinical trials

Authors

  • Andreas Roller Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Iakov I Davydov Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Petra C Schwalie Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Martha L Serrano-Serrano Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Astrid Heller Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, Roche Diagnostics GmbH, Munich, Germany PubMed articlesGoogle scholar articles
  • Nicolas Staedler Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Cláudia S Ferreira Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, Roche Diagnostics GmbH, Munich, Germany PubMed articlesGoogle scholar articles
  • Gabriele Dietmann Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, Roche Diagnostics GmbH, Munich, Germany PubMed articlesGoogle scholar articles
  • Irina Klaman Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, Roche Diagnostics GmbH, Munich, Germany PubMed articlesGoogle scholar articles
  • Alberto Valdeolivas Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Konstanty Korski Roche Product Development, PHC Data, Analytics and Imaging, F. Hoffmann-La Roche Ltd, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Michael A Cannarile Roche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center, Roche Diagnostics GmbH, Munich, Germany PubMed articlesGoogle scholar articles

Citation

Roller A, Davydov II, Schwalie PC, et al
Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and late-phase clinical trials
Online issue publication 
April 22, 2024

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