Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination

Robert A Watson; Weiyu Ye; Chelsea A Taylor; Elsita Jungkurth; Rosalin Cooper; Orion Tong; Tim James; Brian Shine; Monika Hofer; Damian Jenkins; Robert Pell; Eleni Ieremia; Stephanie Jones; David Maldonado-Perez; Ian S D Roberts; Nicholas Coupe; Mark R Middleton; Miranda J Payne; Benjamin P Fairfax

doi:10.1136/jitc-2023-008151

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Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination

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Robert A Watson MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKCancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Weiyu Ye MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKCancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Chelsea A Taylor MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Elsita Jungkurth MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Rosalin Cooper MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Orion Tong MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Tim James Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Brian Shine Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Monika Hofer Department of Neuro Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Damian Jenkins Department of Clinical Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Robert Pell Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Eleni Ieremia Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Stephanie Jones Oxford Centre for Histopathological Research, Oxford University Hospitals NHS Trust, Oxford, UK PubMed articles Google scholar articles
David Maldonado-Perez Oxford Centre for Histopathological Research, Oxford University Hospitals NHS Trust, Oxford, UK PubMed articles Google scholar articles
Ian S D Roberts Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Nicholas Coupe Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Mark R Middleton Department of Oncology, University of Oxford, Oxford, UKCancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Miranda J Payne Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Benjamin P Fairfax MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKCancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles

Citation

Watson RA, Ye W, Taylor CA, et al

Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination

Journal for ImmunoTherapy of Cancer 2024;12:e008151. doi: 10.1136/jitc-2023-008151

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April 24, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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