1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity

Hakimeh Ebrahimi-Nik; Christina K Baumgartner; Arvin Iracheta-Vellve; Keith M Hamel; Kira Olander; Thomas GR Davis; Kathleen A McGuire; Geoff T Halvorsen; Omar I Avila; Chirag Patel; Sarah Kim; Ashwin V Kammula; Audrey J Muscato; Kyle Halliwill; Prasanthi Geda; Kelly Klinge; Zhaoming Xiong; Ryan Duggan; Liang Mu; Mitchell D Yeary; James C Patti; Tyler M Balon; Rebecca Mathew; Carey Backus; Domenick Kennedy; Angeline Chen; Kenton Longenecker; Joseph Klahn; Cara Hrusch; Navasona Krishnan; Charles W Hutchins; Jacqueline Aguado; Marinka Bulic; Payal Tiwari; Kayla J Colvin; Cun Lan Chuong; Ian C Kohnle; Matthew G Rees; Andrew Boghossian; Melissa Ronan; Jennifer A Roth; Meng-Ju Wu; Debattama R Sen; Gabriel K Griffin; Nabeel El-Bardeesy; Patricia Trusk; Meng Sun; Yue Liu; Joshua H Decker; Yi Yang; Stacey Fossey; Wei Qiu; Qi Sun; Marcia N Paddock; Elliot P Farney; Clay Beauregard; Jennifer M Frost; Kathleen B Yates; Philip R Kym; Robert T Manguso

doi:10.1136/jitc-2023-SITC2023.1403-A

Article info

PDF

Regular Abstracts – Part 2

Novel Single-Agent Immunotherapies

1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity

Authors

Hakimeh Ebrahimi-Nik Somerville, MA, USA Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA PubMed articles Google scholar articles
Christina K Baumgartner AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Arvin Iracheta-Vellve AstraZeneca, Wellesley, MA, USA PubMed articles Google scholar articles
Keith M Hamel AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Kira Olander Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Thomas GR Davis Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Kathleen A McGuire AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Geoff T Halvorsen AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Omar I Avila Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Chirag Patel Calico Life Sciences, South San Francisco, CA, USA PubMed articles Google scholar articles
Sarah Kim Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Ashwin V Kammula Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Audrey J Muscato Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Kyle Halliwill AbbVie, San Bruno, CA, USA PubMed articles Google scholar articles
Prasanthi Geda Bristol Myers Squibb, Summit, NJ, USA PubMed articles Google scholar articles
Kelly Klinge AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Zhaoming Xiong AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Ryan Duggan AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Liang Mu AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Mitchell D Yeary Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
James C Patti Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Tyler M Balon Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Rebecca Mathew AbbVie Inc., South San Franscisco, CA, USA PubMed articles Google scholar articles
Carey Backus AbbVie Inc., South San Franscisco, CA, USA PubMed articles Google scholar articles
Domenick Kennedy AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Angeline Chen AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Kenton Longenecker AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Joseph Klahn AbbVie, Elk Grove Village, IL, USA PubMed articles Google scholar articles
Cara Hrusch AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Navasona Krishnan AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Charles W Hutchins AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Jacqueline Aguado AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Marinka Bulic AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Payal Tiwari Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Kayla J Colvin Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Cun Lan Chuong Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Ian C Kohnle Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Matthew G Rees Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Andrew Boghossian Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Melissa Ronan Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Jennifer A Roth Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Meng-Ju Wu Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Debattama R Sen Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA PubMed articles Google scholar articles
Gabriel K Griffin Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Nabeel El-Bardeesy Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA PubMed articles Google scholar articles
Patricia Trusk AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Meng Sun Calico Life Sciences, South San Francisco, CA, USA PubMed articles Google scholar articles
Yue Liu Calico Life Sciences, South San Francisco, CA, USA PubMed articles Google scholar articles
Joshua H Decker AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Yi Yang AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Stacey Fossey AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Wei Qiu AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Qi Sun AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Marcia N Paddock Calico Life Sciences, South San Francisco, CA, USA PubMed articles Google scholar articles
Elliot P Farney AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Clay Beauregard Calico Life Sciences, South San Francisco, CA, USA PubMed articles Google scholar articles
Jennifer M Frost AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Kathleen B Yates Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Philip R Kym AbbVie Inc., North Chicago, IL, USA PubMed articles Google scholar articles
Robert T Manguso Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles

Citation

Ebrahimi-Nik H, Baumgartner CK, Iracheta-Vellve A, et al

1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity

Journal for ImmunoTherapy of Cancer 2023;11:doi: 10.1136/jitc-2023-SITC2023.1403-A

Online issue publication

December 18, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password