1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer

Dig Bijay Mahat; Heena Kumra; Emily Metcalf; Sarah Castro; Kim Nguyen; William W Ho; Ivy Chen; Brandon Sullivan; Leon K Yim; Vikash Chauhan; Arjun Bhutkar; Hernandez Moura Silva; Stefani Spranger; Rakesh K Jain; Phillip A Sharp

doi:10.1136/jitc-2023-SITC2023.1517

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Late-Breaking Abstracts

Checkpoint Blockade Therapy

1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer

Authors

Dig Bijay Mahat Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Heena Kumra Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Emily Metcalf Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Sarah Castro Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Kim Nguyen Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
William W Ho Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Ivy Chen Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Brandon Sullivan Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Leon K Yim Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Vikash Chauhan Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Arjun Bhutkar Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Hernandez Moura Silva Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA PubMed articles Google scholar articles
Stefani Spranger Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles
Rakesh K Jain Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Phillip A Sharp Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA PubMed articles Google scholar articles

Citation

Mahat DB, Kumra H, Metcalf E, et al

1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer

Journal for ImmunoTherapy of Cancer 2023;11:doi: 10.1136/jitc-2023-SITC2023.1517

Online issue publication

October 31, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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