274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Demetrios Kalaitzidis; Mohammed Ghonime; Robert Chain; Nivedita Jaishankar; Davis Settipane; Zinkal Padalia; Lauren Zakas; Meghna Kuppuraju; Paul Tetteh; Mary-Lee Dequeant; Sushant Karnik; Chandirasegaran Massilamany; Brigid McEwan; Henia Dar; Melanie Allen; Laura Serwer; Thao Nguyen; Melanie Butler-Gauthier; Parin Sripakdeevong; Shashwat Nagar; Yin Tang; Nicole Flanagan; Elaine Huang; Shashwant Phuyal; Andrew Dunn; Elizabeth Koch; Erisa Sula; Jacob Waldman; Maria Lei Zhang; Cristian Loaiza; Erin Thorstensen; Keith Steiger; Katie Schum; Kayla Urbaez; Anna Ma; Annie Yang Weaver; Christopher Finch; Sarah Cohen; PK Morrow; Mark Benton; Jonathan Terrett

doi:10.1136/jitc-2023-SITC2023.0274

Article info

Regular and Young Investigator Award Abstracts

Cellular Therapies

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Authors

Demetrios Kalaitzidis CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Mohammed Ghonime CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Robert Chain CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Nivedita Jaishankar CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Davis Settipane CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Zinkal Padalia CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Lauren Zakas CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Meghna Kuppuraju CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Paul Tetteh CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Mary-Lee Dequeant CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Sushant Karnik CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Chandirasegaran Massilamany CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Brigid McEwan CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Henia Dar CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Melanie Allen CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Laura Serwer CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Thao Nguyen CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Melanie Butler-Gauthier CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Parin Sripakdeevong CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Shashwat Nagar CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Yin Tang CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Nicole Flanagan CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Elaine Huang CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Shashwant Phuyal CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Andrew Dunn CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Elizabeth Koch CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Erisa Sula CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Jacob Waldman CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Maria Lei Zhang CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Cristian Loaiza CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Erin Thorstensen CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Keith Steiger CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Katie Schum CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Kayla Urbaez CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Anna Ma CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Annie Yang Weaver CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Christopher Finch CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Sarah Cohen CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
PK Morrow CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Mark Benton CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles
Jonathan Terrett CRISPR Therapeutics, Cambridge, MA, USA PubMed articles Google scholar articles

Citation

Kalaitzidis D, Ghonime M, Chain R, et al

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Journal for ImmunoTherapy of Cancer 2023;11:doi: 10.1136/jitc-2023-SITC2023.0274

Online issue publication

November 02, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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