1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells

Santosh Narayan; Allison P Drain; Nathaniel Swanson; Nicholas Rouillard; Tyler Warner; Nicole Danek; Ken Gareau; Cheryl Black; James Parsons; Anthony Thomas; Jinsheng Liang; Luhua Shen; Tanya Tetrault; Vince Nguyen; Iqraa Priyata; Sarah Vidyasagar; Joshua Francis; Xingyue He; Patrick J Browne; Rebecca C Lamothe; Meghan D Storlie; Gregory J Cost; Thomas M Schmitt; Philip D Greenberg; Smita S Chandran; Christopher A Klebanoff; Ankit Gupta; Damien Hallet; Gary Shapiro; Kim Nguyen; Loic Vincent

doi:10.1136/jitc-2023-SITC2023.1223

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Immuno-Engineering

1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells

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Cite this article as:: Narayan S, Drain AP, Swanson N, et al

1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells

Journal for ImmunoTherapy of Cancer 2023;11:doi: 10.1136/jitc-2023-SITC2023.1223

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