Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)

Jun Masuda; Hitomi Sakai; Junji Tsurutani; Yuko Tanabe; Norikazu Masuda; Tsutomu Iwasa; Masato Takahashi; Manabu Futamura; Koji Matsumoto; Kenjiro Aogi; Hiroji Iwata; Mari Hosonaga; Toru Mukohara; Kiyoshi Yoshimura; Chiyo K Imamura; Sakiko Miura; Toshiko Yamochi; Hidetaka Kawabata; Hiroyuki Yasojima; Nobumoto Tomioka; Kenichi Yoshimura; Toshimi Takano

doi:10.1136/jitc-2023-007126

Article info

PDF

PDF +
Supplementary
Material

Clinical/translational cancer immunotherapy

Original research

Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)

Authors

Jun Masuda Department of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo, JapanDepartment of Medical Oncology, Toranomon Hospital, Minato-ku, Tokyo, Japan PubMed articles Google scholar articles
Hitomi Sakai Advanced Cancer Translational Research Institute, Showa University, Shinagawa-ku, Tokyo, JapanDepartment of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan PubMed articles Google scholar articles
Junji Tsurutani Advanced Cancer Translational Research Institute, Showa University, Shinagawa-ku, Tokyo, Japan PubMed articles Google scholar articles
Yuko Tanabe Department of Medical Oncology, Toranomon Hospital, Minato-ku, Tokyo, Japan PubMed articles Google scholar articles
Norikazu Masuda Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, JapanDepartment of Surgery, Breast Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan PubMed articles Google scholar articles
Tsutomu Iwasa Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan PubMed articles Google scholar articles
Masato Takahashi Department of Breast Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, JapanDepartment of Breast Surgery, Hokkaido University Hospital, Sapporo, Hokkaido, Japan PubMed articles Google scholar articles
Manabu Futamura Department of Surgical Oncology, Graduate School of Medicine, Gifu University, Gifu, Japan PubMed articles Google scholar articles
Koji Matsumoto Department of Medical Oncology, Hyogo Cancer Center, Akashi, Hyogo, Japan PubMed articles Google scholar articles
Kenjiro Aogi Department of Breast Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan PubMed articles Google scholar articles
Hiroji Iwata Department of Breast Oncology, Aichi Cancer Center, Nagoya, Aichi, Japan PubMed articles Google scholar articles
Mari Hosonaga Department of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan PubMed articles Google scholar articles
Toru Mukohara Department of Medical Oncology, National Cancer Center-Hospital East, Kashiwa, Chiba, Japan PubMed articles Google scholar articles
Kiyoshi Yoshimura Department of Clinical Immuno-oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Shinagawa-ku, Tokyo, Japan PubMed articles Google scholar articles
Chiyo K Imamura Advanced Cancer Translational Research Institute, Showa University, Shinagawa-ku, Tokyo, Japan PubMed articles Google scholar articles
Sakiko Miura Department of Pathology, Showa University, Shinagawa-ku, Tokyo, Japan PubMed articles Google scholar articles
Toshiko Yamochi Department of Pathology, Showa University, Shinagawa-ku, Tokyo, Japan PubMed articles Google scholar articles
Hidetaka Kawabata Department of Breast and Endocrine Surgery, Toranomon Hospital, Minato-ku, Tokyo, Japan PubMed articles Google scholar articles
Hiroyuki Yasojima Department of Surgery, Breast Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan PubMed articles Google scholar articles
Nobumoto Tomioka Department of Breast Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan PubMed articles Google scholar articles
Kenichi Yoshimura Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Toshimi Takano Department of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo, JapanDepartment of Medical Oncology, Toranomon Hospital, Minato-ku, Tokyo, Japan PubMed articles Google scholar articles

Citation

Masuda J, Sakai H, Tsurutani J, et al

Journal for ImmunoTherapy of Cancer 2023;11:e007126. doi: 10.1136/jitc-2023-007126

Online issue publication

December 06, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password