AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Vedika Mehra; Giulia Agliardi; Juliana Dias Alves Pinto; Manar S Shafat; Amaia Cadinanos Garai; Louisa Green; Alastair Hotblack; Fred Arce Vargas; Karl S Peggs; Anniek B van der Waart; Harry Dolstra; Martin A Pule; Claire Roddie

doi:10.1136/jitc-2023-007002

Article info

PDF

PDF +
Supplementary
Material

Immune cell therapies and immune cell engineering

Original research

AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Authors

Vedika Mehra Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Giulia Agliardi Research Department of Haematology, University College London, London, UKCentre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital, London, UK PubMed articles Google scholar articles
Juliana Dias Alves Pinto Research Department of Haematology, University College London, London, UKCentre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital, London, UK PubMed articles Google scholar articles
Manar S Shafat Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Amaia Cadinanos Garai Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Louisa Green Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Alastair Hotblack Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Fred Arce Vargas Autolus Ltd, London, UK PubMed articles Google scholar articles
Karl S Peggs Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles
Anniek B van der Waart Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands PubMed articles Google scholar articles
Harry Dolstra Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands PubMed articles Google scholar articles
Martin A Pule Research Department of Haematology, University College London, London, UKAutolus Ltd, London, UK PubMed articles Google scholar articles
Claire Roddie Research Department of Haematology, University College London, London, UK PubMed articles Google scholar articles

Citation

Mehra V, Agliardi G, Dias Alves Pinto J, et al

AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Journal for ImmunoTherapy of Cancer 2023;11:e007002. doi: 10.1136/jitc-2023-007002

Online issue publication

December 06, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password