CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity

Ramin Salehi-Rad; Raymond J Lim; Yushen Du; Linh M Tran; Rui Li; Stephanie L Ong; Zi Ling Huang; Camelia Dumitras; Tianhao Zhang; Stacy J Park; William Crosson; Bitta Kahangi; Jensen Abascal; Christopher Seet; Michael Oh; Maryam Shabihkhani; Manash Paul; Kostyantyn Krysan; Aaron E Lisberg; Edward B Garon; Bin Liu; Steven M Dubinett

doi:10.1136/jitc-2023-006896

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Clinical/translational cancer immunotherapy

Original research

CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity

Authors

Ramin Salehi-Rad Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAMedicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA PubMed articles Google scholar articles
Raymond J Lim Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Yushen Du Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAMedicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China PubMed articles Google scholar articles
Linh M Tran Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAMedicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA PubMed articles Google scholar articles
Rui Li Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Stephanie L Ong Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Zi Ling Huang Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Camelia Dumitras Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Tianhao Zhang Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Stacy J Park Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
William Crosson Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Bitta Kahangi Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Jensen Abascal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Christopher Seet Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Michael Oh Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Maryam Shabihkhani Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA PubMed articles Google scholar articles
Manash Paul Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Kostyantyn Krysan Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Aaron E Lisberg Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Edward B Garon Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Bin Liu Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA PubMed articles Google scholar articles
Steven M Dubinett Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAMedicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA PubMed articles Google scholar articles

Citation

Salehi-Rad R, Lim RJ, Du Y, et al

CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity

Journal for ImmunoTherapy of Cancer 2023;11:e006896. doi: 10.1136/jitc-2023-006896

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December 06, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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