Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts

Margaret Veitch; Kimberly Beaumont; Rebecca Pouwer; Hui Yi Chew; Ian H Frazer; H Peter Soyer; Scott Campbell; Brian W Dymock; Andrew Harvey; Terrie-Anne Cock; James W Wells

doi:10.1136/jitc-2023-006783

Article info

PDF

PDF +
Supplementary
Material

Oncolytic and local immunotherapy

Original research

Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts

Authors

Margaret Veitch Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Kimberly Beaumont Queensland Emory Drug Discovery Initiative, UniQuest, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Rebecca Pouwer Queensland Emory Drug Discovery Initiative, UniQuest, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Hui Yi Chew Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Ian H Frazer Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
H Peter Soyer Frazer Institute, Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, AustraliaDepartment of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Scott Campbell Faculty of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Brian W Dymock Queensland Emory Drug Discovery Initiative, UniQuest, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Andrew Harvey Queensland Emory Drug Discovery Initiative, UniQuest, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Terrie-Anne Cock Queensland Emory Drug Discovery Initiative, UniQuest, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles
James W Wells Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaFrazer Institute, Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia PubMed articles Google scholar articles

Citation

Veitch M, Beaumont K, Pouwer R, et al

Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts

Journal for ImmunoTherapy of Cancer 2023;11:e006783. doi: 10.1136/jitc-2023-006783

Online issue publication

December 06, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password