Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study

Arielle Elkrief; Joao M Victor Alessi; Biagio Ricciuti; Samantha Brown; Hira Rizvi; Isabel R Preeshagul; Xinan Wang; Federica Pecci; Alessandro Di Federico; Giuseppe Lamberti; Jacklynn V Egger; Jamie E Chaft; Charles M Rudin; Gregory J Riely; Mark G Kris; Marc Ladanyi; Yuan Chen; Matthew D Hellmann; Ronglai Shen; Mark M Awad; Adam J Schoenfeld

doi:10.1136/jitc-2023-006994

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Clinical/translational cancer immunotherapy

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Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study

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Arielle Elkrief Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAHuman Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USADepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA PubMed articles Google scholar articles
Joao M Victor Alessi Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Biagio Ricciuti Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Samantha Brown Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Hira Rizvi Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Isabel R Preeshagul Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Xinan Wang Environmental Health, Harvard University, Boston, Massachusetts, USA PubMed articles Google scholar articles
Federica Pecci Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Alessandro Di Federico Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Giuseppe Lamberti Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Jacklynn V Egger Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Jamie E Chaft Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles
Charles M Rudin Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles
Gregory J Riely Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles
Mark G Kris Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles
Marc Ladanyi Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USADepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA PubMed articles Google scholar articles
Yuan Chen Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Matthew D Hellmann Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles
Ronglai Shen Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Mark M Awad Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA PubMed articles Google scholar articles
Adam J Schoenfeld Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USAWeill Cornell Medical College, New York, New York, USA PubMed articles Google scholar articles

Citation

Elkrief A, Alessi JMV, Ricciuti B, et al

Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study

Journal for ImmunoTherapy of Cancer 2023;11:e006994. doi: 10.1136/jitc-2023-006994

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January 24, 2024

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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