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  • 2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

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Basic tumor immunology
Original research
2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

Authors

  • Banglun Pan Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Zhanfei Chen Department of Laboratory Medicine, Affiliated Hospital of Putian University, Putian, ChinaKey Laboratory of Medical Microecology (Putian University), Fujian Province University, Putian, China PubMed articlesGoogle scholar articles
  • Xiaoxia Zhang Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Zengbin Wang Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Yuxin Yao Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Xiaoxuan Wu Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Jiacheng Qiu Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles
  • Hua Lin Department of Laboratory Medicine, Affiliated Hospital of Putian University, Putian, ChinaKey Laboratory of Medical Microecology (Putian University), Fujian Province University, Putian, China PubMed articlesGoogle scholar articles
  • Liumin Yu Department of Laboratory Medicine, Affiliated Hospital of Putian University, Putian, China PubMed articlesGoogle scholar articles
  • Haijian Tu School of Basic Medical Sciences, Putian University, Putian, China PubMed articlesGoogle scholar articles
  • Nanhong Tang Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaCancer Center of Fujian Medical University, Fujian Medical University Union Hospital, Fuzhou, China PubMed articlesGoogle scholar articles

Citation

Pan B, Chen Z, Zhang X, et al
2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis
Journal for ImmunoTherapy of Cancer 2023;11:e006817. doi: 10.1136/jitc-2023-006817
Online issue publication 
June 14, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.