Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

Anil Kumar; Adeleh Taghi Khani; Caroline Duault; Soraya Aramburo; Ashly Sanchez Ortiz; Sung June Lee; Anthony Chan; Tinisha McDonald; Min Huang; Norman J. Lacayo; Kathleen M. Sakamoto; Jianhua Yu; Christian Hurtz; Martin Carroll; Sarah K. Tasian; Lucy Ghoda; Guido Marcucci; Zhaohui Gu; Steven T. Rosen; Saro Armenian; Shai Izraeli; Chun-Wei Chen; Michael A. Caligiuri; Stephen J. Forman; Holden T. Maecker; Srividya Swaminathan

doi:10.1136/jitc-2022-006649

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Immune cell therapies and immune cell engineering

Original research

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

Authors

Anil Kumar Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Adeleh Taghi Khani Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Caroline Duault The Human Immune Monitoring Center (HIMC), Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Soraya Aramburo Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Ashly Sanchez Ortiz Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Sung June Lee Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Anthony Chan Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Tinisha McDonald The Hematopoietic Tissue Biorepository/Research Pathology Shared Resources, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Min Huang Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Norman J. Lacayo Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Kathleen M. Sakamoto Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Jianhua Yu Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Christian Hurtz Department of Cancer and Cellular Biology, Fels Cancer Institute for Personalized Medicine Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Martin Carroll Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Sarah K. Tasian Department of Pediatrics, Division of Oncology, The Children's Hospital, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Lucy Ghoda Hematological Malignancies Translational Science, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Guido Marcucci The Hematopoietic Tissue Biorepository/Research Pathology Shared Resources, City of Hope, Duarte, California, USADepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USAHematological Malignancies Translational Science, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Zhaohui Gu Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Steven T. Rosen Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Saro Armenian Department of Pediatrics, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Shai Izraeli Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USAHematology-Oncology Department, Tel Aviv University, Tel Aviv, Israel PubMed articles Google scholar articles
Chun-Wei Chen Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USA PubMed articles Google scholar articles
Michael A. Caligiuri Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Stephen J. Forman Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Holden T. Maecker The Human Immune Monitoring Center (HIMC), Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Srividya Swaminathan Department of Systems Biology, City of Hope Beckman Research Institute, Monrovia, California, USADepartment of Pediatrics, City of Hope, Duarte, California, USA PubMed articles Google scholar articles

Citation

Kumar A, Taghi Khani A, Duault C, et al

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

Journal for ImmunoTherapy of Cancer 2023;11:e006649. doi: 10.1136/jitc-2022-006649

Online issue publication

May 22, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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