Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment

Pengfei Xu; Joy C Yang; Bo Chen; Christopher Nip; Jonathan E Van Dyke; Xiong Zhang; Hong-Wu Chen; Christopher P Evans; William J Murphy; Chengfei Liu

doi:10.1136/jitc-2022-006581

Article info

Basic tumor immunology

Original research

Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment

Authors

Pengfei Xu Department of Urologic Surgery, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Joy C Yang Department of Urologic Surgery, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Bo Chen Department of Urologic Surgery, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Christopher Nip Department of Urologic Surgery, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Jonathan E Van Dyke Flow Cytometry Core, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Xiong Zhang Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA PubMed articles Google scholar articles
Hong-Wu Chen Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USAUniversity of California Davis Comprehensive Cancer Center, Sacramento, California, USA PubMed articles Google scholar articles
Christopher P Evans Department of Urologic Surgery, University of California Davis, Sacramento, California, USAUniversity of California Davis Comprehensive Cancer Center, Sacramento, California, USA PubMed articles Google scholar articles
William J Murphy University of California Davis Comprehensive Cancer Center, Sacramento, California, USADepartment of Dermatology and Department of Internal Medicine, University of California Davis, Sacramento, California, USA PubMed articles Google scholar articles
Chengfei Liu Department of Urologic Surgery, University of California Davis, Sacramento, California, USAUniversity of California Davis Comprehensive Cancer Center, Sacramento, California, USA PubMed articles Google scholar articles

Citation

Xu P, Yang JC, Chen B, et al

Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment

Journal for ImmunoTherapy of Cancer 2023;11:e006581. doi: 10.1136/jitc-2022-006581

Online issue publication

May 05, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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