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  • Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression

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Basic tumor immunology
Original research
Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression

Authors

  • Veronica Finisguerra de Duve Institute, UCLouvain, Brussels, BelgiumLudwig Institute for Cancer Research, de Duve Institute, Brussels, BelgiumWalloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Tereza Dvorakova de Duve Institute, UCLouvain, Brussels, BelgiumLudwig Institute for Cancer Research, de Duve Institute, Brussels, BelgiumWalloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Matteo Formenti de Duve Institute, UCLouvain, Brussels, BelgiumLudwig Institute for Cancer Research, de Duve Institute, Brussels, BelgiumWalloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Pierre Van Meerbeeck de Duve Institute, UCLouvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Lionel Mignion Biomedical Magnetic Resonance (REMA) Group, Louvain Drug Research Institute, UCLouvain, Brussels, BelgiumNuclear and Electron Spin Technologies (NEST) Platform, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Bernard Gallez Biomedical Magnetic Resonance (REMA) Group, Louvain Drug Research Institute, UCLouvain, Brussels, BelgiumNuclear and Electron Spin Technologies (NEST) Platform, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium PubMed articlesGoogle scholar articles
  • Benoit J Van den Eynde de Duve Institute, UCLouvain, Brussels, BelgiumLudwig Institute for Cancer Research, de Duve Institute, Brussels, BelgiumWalloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, BelgiumNuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles

Citation

Finisguerra V, Dvorakova T, Formenti M, et al
Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression
Journal for ImmunoTherapy of Cancer 2023;11:e005719. doi: 10.1136/jitc-2022-005719
Online issue publication 
May 05, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.